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Program

 

The international Helmholtz Drug Discovery Conference (HDDC) is established by the Helmholtz Drug Research Initiative. In 2018 the international HDDC will be organized by the Helmholtz Zentrum München.

 

The meeting will run from 12:45 Thu, Apr 26 to  15:30, Fri, Apr 27, 2018

 

Program

Download program [PDF]


Thursday, April 26, 2018

12:45

Welcome
Mark Brönstrup, Martin Göttlicher, Michael Sattler                                                 

 

SESSION 1Lead discovery
Chair: Mark Brönstrup (HZI Braunschweig)

13:00

Jens-Peter von Kries (FMP Berlin)
A short story of chemical biology

13:25

Christopher J. Schofield (University of Oxford)
Targeting metallo-enzymes for antibiotic resistance and human diseases

13:50

Short talk:  Andreas Martin Kany (HZI Braunschweig)
Development of inhibitors targeting elastase (LasB) from Pseudomonas aeruginosa and collagenase H (ColH)
from Clostridium histolyticum

14:05

Short talk: Thomas Conlon (Helmholtz Zentrum München)
A novel therapeutic target inhibition of Oxysterol pathways diminishes immune pathogenesis of
chronic obstructive pulmonary disease (COPD)

14:20

Short talk:  Elena De Vita (DKFZ Heidelberg)
Development and characterization of small molecule KLK6 inhibitors

14:35

Ralf Mazitschek (Harvard University)
Chemogenomic approaches to spatiotemporal regulation of HDAC activity

15:00

            Coffee Break

 

SESSION 2 - Novel targets and deconvolution
Chair: Aubry Miller (DKFZ Heidelberg)

15:30

Herbert Waldmann (MPI Dortmund)
Chemotype - Phenotype – Target

15:55

Stephan Sieber (TU München)
Chemical proteome mining to fight multiresistant bacteria

16:20

Short talk: Harald Schwalbe (JWG Universität Frankfurt)
Surprises in inhibitor development: Towards Eph-receptor inhibitors

 

SESSION 3 – Structure-based and computational drug discovery
Chair: Oliver Plettenburg (Helmholtz Zentrum München)

16:35

Anna Hirsch (Helmholtz Institute for Pharmaceutical Research Saarland – HIPS)
Exploring hit-identification strategies for anti-infective development

17:00

Grzegorz Popowicz (Helmholtz Zentrum München)
Glycosomal transport inhibition - a novel strategy against Trypanosoma parasites

17:25

            Coffee Break

17:55

Wolfgang Jahnke (Novartis)
NMR in drug discovery: From hit finding to mechanism of action

18:20

Short talk: Christian Feiler (Helmholtz Zentrum Berlin)
Crystallographic fragment-screening (CFS) at the macromolecular beamlines at BESSY II operated
by Helmholtz Zentrum Berlin

18:35

Gisbert Schneider (ETH Zürich)           ITN AEGIS Lecture
The Automation of Drug Design

19:00

            Buffet Dinner

19:30
-    
21:00


POSTER SESSION

 

 Friday, April 27, 2018

 

SESSION 3  cont’d – Structure-based and computational drug discovery
Chair: Eugenio Fava (DZNE Bonn)

9:00

Elisabetta Chiarparin (Astra Zeneca)
The role of free ligand conformations in structure-based design of protein-protein interaction inhibitors

9:25

Short talk: Felix Hausch (TU Darmstadt)
Selective FKBP51 ligands by conformation-specific binding

9:40

Short talk: Thorsten Berg (Leipzig University)
Natural product-inspired development of selective small-molecule inhibitors of the transcription factor STAT5b

9:55

Short talk: Lisa Diez (MDC Berlin)
Structure-based discovery of amyloid-ß nucleation modulators using a fluorescence polarization-based aggregation assay

10:10

Andreas Bender (University of Cambridge)
Chemical and biological data - from compound selection to mode of action analysis (and back again)

10:35

            Coffee Break

 

SESSION 4 – Chemistry for probing biology
Chair: Jens-Peter von Kries
(FMP Berlin)

11:05

Thomas Mayer (University of Konstanz)
Chemical biology approach to investigate mitosis in mammalian cells

11:30

Short talk: Alexander Pautsch (Boehringer Ingelheim)
Discovery of a selective probe for the citrate transporter SLC13A5

11:45

Kai Johnsson (MPI Heidelberg)
Fluorescent and bioluminescent sensor proteins

12:10

Short talk: Andreas Brunschweiger (TU Dortmund)
Synthesis strategies to genetically tagged small molecule libraries

12:25

Dorothea Fiedler (FMP Berlin)
Elucidating the functions of inositol pyrophosphate messengers with chemical tools

12:50

            Lunch buffet

 

SESSION 5 – Peptides & more
Chair: Michael Bader (MDC Berlin)

13:45

Peter Seeberger (MPI Potsdam)
Glycocconjugate vaccines against bacterial infections based on synthetic glycans

14:10

Christian Hackenberger (FMP Berlin)
The power of chemoselectivity: Functional antibody-conjugates for extra- and intracellular targeting

14:35

Short talk: Armin Bauer (Sanofi-Aventis)
Evaluation of the tetrapeptide GE81112A:  Total synthesis, structure revision and in-depth lead profiling

14:50

Annette Beck-Sickinger (Leipzig University)
Peptide drugs to target GPCR - state-of-the art and innovative application

15:15

Announcement of poster prizes

END/FAREWELL   Mark Brönstrup, Martin Göttlicher, Michael Sattler

 

 

 

15:45
-    
18:00

Free Satellite workshop "Modeling for Anyone", BioSolveIT

IMPORTANT: Participation is free but please register via e-mail as described here.

Poster in portrait format  A0, poster walls are numbered, numbering corresponds to page number in abstract book

The three best posters will be awarded a posterprize donated by CHEMMEDCHEM and Fachgruppe Chemische Biologie of GDCh

Invited Speakers

Annette Beck-Sickinger

Peptide drugs to target GPCR- state-of-the art and innovative application

Leipzig University, Germany

Andreas Bender

Chemical and biological data - from compound selection to mode of action analysis (and back again)

University of Cambridge, UK

Elisabetta Chiarparin

The role of free ligand conformations in structure-based design of protein-protein interaction inhibitors

AstraZenecaUK, UK   

Dorothea Fiedler

Elucidating the functions of inositol pyrophosphate messengers with chemical tools

Leibniz-Forschungsinstitut für Molekulare Pharmakologie
im Forschungsverbund Berlin e.V.  
(FMP)

Christian Hackenberger

The power of chemoselectivity: Functional antibody-conjugates for extra- and intracellular targeting  

Leibniz-Forschungsinstitut für Molekulare Pharmakologie
im Forschungsverbund Berlin e.V.  
(FMP)

Anna Hirsch

Exploring hit-identification strategies for anti-infective development

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany

Wolfgang Jahnke

NMR in drug discovery: From hit finding to mechanism of action 

Novartis AG, Switzerland

Kai Johnsson

Fluorescent and bioluminescent sensor proteins

Max-Planck-Institute for Medical Research, Heidelberg, Germany

Jens Peter von Kries

A short story of chemical biology

Leibniz-Forschungsinstitut für Molekulare Pharmakologie
im Forschungsverbund Berlin e.V.  
(FMP)

 

 

Organisation

Helmholtz Drug Research Initiative

 

 

Local Organisation

Prof. Dr. Michael Sattler

Institute of Structural Biology
Helmholtz Zentrum München
Ingolstädter Landstr. 1
85764 Neuherberg

Phone: +49 (0)89 3187-3800

Email

http://www.helmholtz-muenchen.de/stb

 

Prof. Dr. Martin Göttlicher

Helmholtz Zentrum München
German Research Center for Environmental Health
Institute of Molecular Toxicology and Pharmacology
Ingolstädter Landstr. 1
D-85764 Neuherberg

Phone: +49 89 3187-2446

Email

https://www.helmholtz-muenchen.de/toxi

 

Dr. Eva Schlosser

Institute of Structural Biology
Helmholtz Zentrum München
Ingolstädter Landstr. 1
85764 Neuherberg

Phone: +49 (0)89 3187-2908

Email