12:45

Welcome
Mark Brönstrup, Martin Göttlicher, Michael Sattler                                                 

SESSION 1 – Lead discovery
Chair: Mark Brönstrup (HZI Braunschweig)

13:00

Jens-Peter von Kries (FMP Berlin)
A short story of chemical biology

13:25

Christopher J. Schofield (University of Oxford)
Targeting metallo-enzymes for antibiotic resistance and human diseases

13:50

Short talk:  Andreas Martin Kany (HZI Braunschweig)
Development of inhibitors targeting elastase (LasB) from Pseudomonas aeruginosa and collagenase H (ColH)
from Clostridium histolyticum

14:05

Short talk: Thomas Conlon (Helmholtz Zentrum München)
A novel therapeutic target inhibition of Oxysterol pathways diminishes immune pathogenesis of
chronic obstructive pulmonary disease (COPD)

14:20

Short talk:  Elena De Vita (DKFZ Heidelberg)
Development and characterization of small molecule KLK6 inhibitors

14:35

Ralf Mazitschek (Harvard University)
Chemogenomic approaches to spatiotemporal regulation of HDAC activity

15:00

            Coffee Break

SESSION 2 - Novel targets and deconvolution
Chair: Aubry Miller (DKFZ Heidelberg)

15:30

Herbert Waldmann (MPI Dortmund)
Chemotype - Phenotype – Target

15:55

Stephan Sieber (TU München)
Chemical proteome mining to fight multiresistant bacteria

16:20

Short talk: Harald Schwalbe (JWG Universität Frankfurt)
Surprises in inhibitor development: Towards Eph-receptor inhibitors

SESSION 3 – Structure-based and computational drug discovery
Chair: Oliver Plettenburg (Helmholtz Zentrum München)

16:35

Anna Hirsch (Helmholtz Institute for Pharmaceutical Research Saarland – HIPS)
Exploring hit-identification strategies for anti-infective development

17:00

Grzegorz Popowicz (Helmholtz Zentrum München)
Glycosomal transport inhibition - a novel strategy against Trypanosoma parasites

17:25

            Coffee Break

17:55

Gisbert Schneider (ETH Zürich)        ITN AEGIS Lecture
The automation of drug design

18:20

Short talk: Christian Feiler (Helmholtz Zentrum Berlin)
Crystallographic fragment-screening (CFS) at the macromolecular beamlines at BESSY II operated
by Helmholtz Zentrum Berlin

18:35

Wolfgang Jahnke (Novartis)
NMR in drug discovery: From hit finding to mechanism of action

19:00

            Buffet Dinner

19:30
-    
21:00

POSTER SESSION

SESSION 3  cont’d – Structure-based and computational drug discovery
Chair: Eugenio Fava (DZNE Bonn)

9:00

Elisabetta Chiarparin (Astra Zeneca)
The role of free ligand conformations in structure-based design of protein-protein interaction inhibitors

9:25

Short talk: Felix Hausch (TU Darmstadt)
Selective FKBP51 ligands by conformation-specific binding

9:40

Short talk: Thorsten Berg (Leipzig University)
Natural product-inspired development of selective small-molecule inhibitors of the transcription factor STAT5b

9:55

Short talk: Lisa Diez (MDC Berlin)
Structure-based discovery of amyloid-ß nucleation modulators using a fluorescence polarization-based aggregation assay

10:10

Andreas Bender (University of Cambridge)
Chemical and biological data - from compound selection to mode of action analysis (and back again)

10:35

            Coffee Break

SESSION 4 – Chemistry for probing biology
Chair: Jens-Peter von Kries (FMP Berlin)

11:05

Thomas Mayer (University of Konstanz)
Chemical biology approach to investigate mitosis in mammalian cells

11:30

Short talk: Alexander Pautsch (Boehringer Ingelheim)
Discovery of a selective probe for the citrate transporter SLC13A5

11:45

Kai Johnsson (MPI Heidelberg)
Fluorescent and bioluminescent sensor proteins

12:10

Short talk: Andreas Brunschweiger (TU Dortmund)
Synthesis strategies to genetically tagged small molecule libraries

12:25

Dorothea Fiedler (FMP Berlin)
Elucidating the functions of inositol pyrophosphate messengers with chemical tools

12:50

            Lunch buffet

SESSION 5 – Peptides & more
Chair: Michael Bader (MDC Berlin)

13:45

Peter Seeberger (MPI Potsdam)
Glycoconjugate vaccines against bacterial infections based on synthetic glycans

14:10

Christian Hackenberger (FMP Berlin)
The power of chemoselectivity: Functional antibody-conjugates for extra- and intracellular targeting

14:35

Short talk: Armin Bauer (Sanofi-Aventis)
Evaluation of the tetrapeptide GE81112A:  Total synthesis, structure revision and in-depth lead profiling

14:50

Annette Beck-Sickinger (Leipzig University)
Peptide drugs to target GPCR - state-of-the art and innovative application

15:15

Announcement of poster prizes

END/FAREWELL   Mark Brönstrup, Martin Göttlicher, Michael Sattler

15:45
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18:00

Free Satellite workshop "Modeling for Anyone", BioSolveIT

IMPORTANT: Participation is free but please register via e-mail as described here.